Pharmacokinetics of olanzapine long-acting injection
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of olanzapine long-acting injection: the clinical perspective
Olanzapine long-acting injection (OLAI) is a sustained-release depot antipsychotic for the treatment of schizophrenia in adults. Our objective was to explain the pharmacokinetics of OLAI to provide clinical insight. Simulation models and data from clinical trials are presented. Olanzapine concentrations were observed immediately upon injection. Half-life was ∼30 days, controlled by the slow rat...
متن کاملPatient perspectives in the development and use of long-acting antipsychotics in schizophrenia: focus on olanzapine long-acting injection
Schizophrenia is a chronic mental disorder generally treated with antipsychotic medication. However, non-adherence and partial adherence to antipsychotic medication treatment is common and long-acting injectable "depot" preparations of antipsychotic medications have been used as an alternative to oral medication therapy for patients for whom adherence is a clinically significant problem, as wel...
متن کاملIVIVC from Long Acting Olanzapine Microspheres
In this study, four PLGA microsphere formulations of Olanzapine were characterized on the basis of their in vitro behavior at 37°C, using a dialysis based method, with the goal of obtaining an IVIVC. In vivo profiles were determined by deconvolution (Nelson-Wagner method) and using fractional AUC. The in vitro and in vivo release profiles exhibited the same rank order of drug release. Further, ...
متن کاملProfile of olanzapine long-acting injection for the maintenance treatment of adult patients with schizophrenia
Olanzapine long-acting injection (OLAI) is a crystalline salt composed of olanzapine and pamoic acid, which permits a depot intramuscular formulation of olanzapine. The half-life of olanzapine pamoate is 30 days, and its steady state is reached approximately at 12 weeks. Oral supplementation of olanzapine is not required during OLAI initiation, according to Eli Lilly recommendations, although a...
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ژورنال
عنوان ژورنال: International Clinical Psychopharmacology
سال: 2014
ISSN: 0268-1315
DOI: 10.1097/yic.0000000000000040